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Osteoarthritis

Metabolomic characterization of metabolic phenotypes in OA

Nature Reviews Rheumatology volume 8, pages 130–132 (2012)Cite this article

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Increasing evidence implicates metabolic dysfunction in the development and progression of osteoarthritis (OA). Large-scale 'omics' studies, particularly metabolomics, have the potential to answer many questions relating to the pathogenesis of so-called 'metabolic OA' and other OA phenotypes, and could be key to the identification of novel biomarkers for these conditions.

In a study recently published in Osteoarthritis & Cartilage, Adams et al.1 used metabolomic tools to identify a metabolic profile for human synovial tissue from patients with end-stage osteoarthritis (OA) that was distinct from that observed for control samples from patients with limited or no evidence of this disease. Their results highlight the potential of metabolomic analyses to provide an alternative perspective of the altered biochemical processes responsible for OA onset and/or progression.

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Figure 1: Development of analytical platforms for OA biomarker discovery and validation.

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Authors and Affiliations

  1. Rheumatology Division, ProteoRed/ISCIII Proteomic Group, INIBIC-Hospital Universitario A Coruña, As Xubias S/N, 15006-A, Coruña, Spain

    Francisco J. Blanco & Cristina Ruiz-Romero

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  1. Francisco J. Blanco
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  2. Cristina Ruiz-Romero
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Correspondence to Francisco J. Blanco.

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The authors declare no competing financial interests.

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Blanco, F., Ruiz-Romero, C. Metabolomic characterization of metabolic phenotypes in OA. Nat Rev Rheumatol 8, 130–132 (2012). https://doi.org/10.1038/nrrheum.2012.11

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