Increasing evidence implicates metabolic dysfunction in the development and progression of osteoarthritis (OA). Large-scale 'omics' studies, particularly metabolomics, have the potential to answer many questions relating to the pathogenesis of so-called 'metabolic OA' and other OA phenotypes, and could be key to the identification of novel biomarkers for these conditions.
Subscribe to Journal
Get full journal access for 1 year
only $17.75 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Adams, S. B. et al. Global metabolic profiling of human osteoarthritic synovium. Osteoarthritis Cartilage 20, 64–67 (2012).
Ruiz-Romero, C. & Blanco, F. J. Proteomics role in the search for improved diagnosis, prognosis and treatment of osteoarthritis. Osteoarthritis Cartilage 18, 500–509 (2010).
Nicholson, J. K. & Wilson, I. D. Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat. Rev. Drug Discov. 2, 668–676 (2003).
Zhai, G. et al. Serum branched-chain amino acid to histidine ratio: a novel metabolomics biomarker of knee osteoarthritis. Ann. Rheum. Dis. 69, 1227–1231 (2010).
Lamers, R. J. et al. Identification of an urinary metabolite profile associated with osteoarthritis. Osteoarthritis Cartilage 13, 762–768 (2005).
Blanco, F. J., Rego, I. & Ruiz-Romero, C. The role of mitochondria in osteoarthritis. Nat. Rev. Rheumatol. 7, 161–169 (2011).
Berenbaum, F. Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype. Ann. Rheum. Dis. 70, 1354–1356 (2011).
Feder, J. et al. Parental diabetes status reveals association of mitochondrial DNA haplogroup J1 with type 2 diabetes. BMC Med. Genet. 10, 60 (2009).
Niemi, A. K. et al. Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. Hum. Genet. 112, 29–33 (2003).
Yang, T. L. et al. Genetic association study of common mitochondrial variants on body fat mass. PLoS ONE 6, e21595 (2011).
The authors declare no competing financial interests.
About this article
Cite this article
Blanco, F., Ruiz-Romero, C. Metabolomic characterization of metabolic phenotypes in OA. Nat Rev Rheumatol 8, 130–132 (2012). https://doi.org/10.1038/nrrheum.2012.11
Can joint fluid metabolic profiling (or “metabonomics”) reveal biomarkers for osteoarthritis and inflammatory joint disease?
Bone & Joint Research (2020)
Journal of Tissue Engineering and Regenerative Medicine (2019)
Current Rheumatology Reports (2019)
Stem Cells International (2019)
Prevalence of and Risk Factors for Total Hip and Knee Replacement in Retired National Football League Athletes
The American Journal of Sports Medicine (2019)