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Rheumatoid arthritis

When should we use rituximab to treat RA?

A decade and a half of rapid progress in treating rheumatoid arthritis (RA) has left clinicians with many options, yet few validated guidelines on how best to use them. What difference will new recommendations on the use of rituximab make to clinical practice?

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References

  1. Yazici, Y. Treatment of rheumatoid arthritis: we are getting there. Lancet 374, 178–180 (2009).

    Article  Google Scholar 

  2. Buch, M. H. et al. Updated consensus statement on the use of rituximab in patients with rheumatoid arthritis. Ann. Rheum. Dis. 70, 909–920 (2011).

    Article  CAS  Google Scholar 

  3. Saunders, S. A. et al. Triple therapy in early active rheumatoid arthritis: a randomized, single-blind, controlled trial comparing step-up and parallel treatment strategies. Arthritis Rheum. 58, 1310–1317 (2008).

    Article  CAS  Google Scholar 

  4. Soubrier, M. et al. Evaluation of two strategies (initial methotrexate monotherapy vs its combination with adalimumab) in management of early active rheumatoid arthritis: data from the GUEPARD trial. Rheumatology (Oxford) 48, 1429–1434 (2009).

    Article  CAS  Google Scholar 

  5. Gibofsky, A. & Yazici, Y. Treatment of rheumatoid arthritis: strategies for achieving optimal outcomes. Ann. Rheum. Dis. 69, 941–942 (2010).

    Article  Google Scholar 

  6. Tak, P. P. et al. Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial. Ann. Rheum. Dis. 70, 39–46 (2011).

    Article  CAS  Google Scholar 

  7. Yazici, Y. & Yazici, H. Tumor necrosis factor α inhibitors, methotrexate or both? An inquiry into the formal evidence for when they are to be used in rheumatoid arthritis. Clin. Exp. Rheumatol. 26, 449–452 (2008).

    CAS  PubMed  Google Scholar 

  8. Yazici, Y., Adler, N. M. & Yazici, H. Most tumour necrosis factor inhibitor trials in rheumatology are undeservedly called 'efficacy and safety' trials: a survey of power considerations. Rheumatology (Oxford) 47, 1054–1057 (2008).

    Article  CAS  Google Scholar 

  9. Paterson, K. R. Events per person year. Can obscure the true risk of certain adverse drug reactions. BMJ 310, 1470 (1995).

    Article  CAS  Google Scholar 

Download references

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Competing interests

Y. Yazici is a consultant for, and has received speakers bureau honoraria from, BMS and Genentech, and is also a consultant for Celgene, Centocor, Merck, Pfizer and UCB.

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Yazici, Y. When should we use rituximab to treat RA?. Nat Rev Rheumatol 7, 379–380 (2011). https://doi.org/10.1038/nrrheum.2011.79

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