OA is not a disease in short supply of phenotypic definitions. Indeed, numerous classification options complicate the design of genetic studies seeking associations within the obscuring array of heterogeneity. New recommendations offer some progress toward clarifying OA definitions, but much-needed guidelines are wanting.
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Acknowledgements
For supporting his research John Loughlin acknowledges Arthritis Research UK, the UK National Institute for Health Research (NIHR) Biomedical Research Center for Ageing and Age-related Disease award to the Newcastle upon Tyne Hospitals NHS Foundation Trust and the Oliver Bird Rheumatism Program.
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Loughlin, J. All types of trouble—defining OA in the genomic era. Nat Rev Rheumatol 7, 200–201 (2011). https://doi.org/10.1038/nrrheum.2011.26
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DOI: https://doi.org/10.1038/nrrheum.2011.26
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FTO variant is not associated with osteoarthritis in the Chinese Han population: replication study for a genome-wide association study identified risk loci
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