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Rheumatoid arthritis

Circadian and circannual rhythms in RA

Early symptoms of arthritis either resolve spontaneously or progress into erosive disease; being able to predict the disease course would inform decisions about intensive early therapy. One predictive factor, according to a new multicenter study, is the season of first symptoms—so how does the Earth's movement influence disease progression?

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Figure 1: Clinical symptoms in patients with RA are influenced by the regular alternation of sunlight and darkness, in circadian and circannual biological rhythms.


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Cutolo, M. Circadian and circannual rhythms in RA. Nat Rev Rheumatol 7, 500–502 (2011).

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