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CyTOF—the next generation of cell detection

A Correction to this article was published on 01 October 2012

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A new single cell detection technology allows simultaneous measurement of up to 100 surface markers and signaling proteins of immune cells. This method provides the opportunity to make great advances into the scientific understanding of rheumatic disease and the provision of individualized patient care.

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  • 01 October 2012

    In the version of this article initially published in print and online, the author did not include an acknowledgement of grant support as required by his funding policy. This omission has been corrected for the HTML and PDF versions of the article.


  1. Bendall, S. C. et al. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science 332, 687–696 (2011).

    Article  CAS  Google Scholar 

  2. Crow, M. K. Type I interferon in organ-targeted autoimmune and inflammatory diseases. Arthritis Res. Ther. 12 (Suppl. 1), S5 (2010).

    Article  CAS  Google Scholar 

  3. Obermoser, G. & Pascual, V. The interferon-α signature of systemic lupus erythematosus. Lupus 19, 1012–1019 (2010).

    Article  CAS  Google Scholar 

  4. Lande, R. et al. Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci. Transl. Med. 3, 73ra19 (2011).

    Article  Google Scholar 

  5. Balboni, I. et al. Multiplexed protein array platforms for analysis of autoimmune diseases. Annu. Rev. Immunol. 24, 391–418 (2006).

    Article  CAS  Google Scholar 

  6. Silverman, G. J. et al. Genetic imprinting of autoantibody repertoires in systemic lupus erythematosus patients. Clin. Exp. Immunol. 153, 102–116 (2008).

    Article  CAS  Google Scholar 

  7. Graham, R. R. et al. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat. Genet. 38, 550–555 (2006).

    Article  CAS  Google Scholar 

  8. Bauer, J. W. et al. Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus. PLoS Med. 3, e491 (2006).

    Article  Google Scholar 

  9. Bauer, J. W. et al. Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation study. Arthritis Rheum. 60, 3098–3107 (2009).

    Article  CAS  Google Scholar 

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P. J. Utz was the recipient of a Donald E. and Delia B. Baxter Foundation Career Development Award and his work is supported by National Heart, Lung, and Blood Institute (NHLBI) Proteomics contract HHSN288201000034C, Proteomics of Inflammatory Immunity and Pulmonary Arterial Hypertension, NIH grants 5 U19-AI082719, 5 U19-AI050864, 5 U19-AI056363, 1 U19 AI090019 and 4 U19 AI090019, Canadian Institutes of Health Research grant 2 OR-92141, Alliance for Lupus Research grant number 21858, a gift from the Ben May Trust and a gift from the Floren Family Trust, and the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement number 261382.

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Correspondence to Paul J. Utz.

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Cheung, R., Utz, P. CyTOF—the next generation of cell detection. Nat Rev Rheumatol 7, 502–503 (2011).

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