A key component of Paget disease of bone is a localized increase in osteoclastic activity, which might be attributable, in part, to mutations in the sequestosome 1 gene. A study has identified three new genes that regulate osteoclasts and are implicated in Paget disease; however, the clinical utility of these findings remains questionable.
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Singer, F., Leach, R. Do all Paget disease risk genes incriminate the osteoclast?. Nat Rev Rheumatol 6, 502–503 (2010). https://doi.org/10.1038/nrrheum.2010.137
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DOI: https://doi.org/10.1038/nrrheum.2010.137
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