The current treatment options for Raynaud phenomenon are often ineffective and can have undesirable adverse effects. Topical, or transdermal, treatments that increase digital blood flow without systemic adverse effects are, therefore, an attractive option. A novel topical nitroglycerin formulation has shown promise in treating Raynaud attacks.
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References
Chung, L. et al. MQX-503, a novel formulation of nitroglycerin, improves the severity of Raynaud's phenomenon. Arthritis Rheum. 60, 870–877 (2009).
Kleckner, M. S., Allen, E. V. & Wakim, K. G. The effect of local application of glyceryl trinitrate (nitroglycerine) on Raynaud's disease and Raynaud's phenomenon: studies on blood flow and clinical manifestations. Circulation 3, 681–689 (1951).
Francks, A. G. Topical glyceryl trinitrate as adjunctive treatment in Raynaud's disease. Lancet 1, 76–77 (1982).
Anderson, M. E. et al. Digital vascular response to topical glyceryl trinitrate, as measured by laser Doppler imaging, in primary Raynaud's phenomenon and systemic sclerosis. Rheumatology (Oxf.) 41, 324–328 (2002).
Teh, L. S. et al. Sustained-release transdermal glyceryl trinitrate patches as a treatment for primary and secondary Raynaud's phenomenon. Br. J. Rheumatol. 34, 636–641 (1995).
Merkel, P. A. et al. Measuring disease activity and functional status in patients with scleroderma and Raynaud's phenomenon. Arthritis Rheum. 46, 2410–2420 (2002).
Thompson, A. E. & Pope, J. E. Calcium channel blockers for primary Raynaud's phenomenon: a meta-analysis. Rheumatology (Oxf.) 44, 145–150 (2005).
Thompson, A. E., Shea, B., Welch, V., Fenlon, D. & Pope, J. E. Calcium-channel blockers for Raynaud's phenomenon in systemic sclerosis. Arthritis Rheum. 44, 1841–1847 (2001).
Belch, J. et al. MQX-503, a novel topical nitroglycerin formulation, improves severity of symptoms associated with Raynaud's phenomenon. Arthritis Rheum. 58 (Suppl.), S622 (2008).
Lewis, T. Experiments relating to the peripheral mechanism involved in spasmodic arrest of the circulation in the fingers, a variety of Raynaud's disease. Heart 15, 7–101 (1929).
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The author declared that she has received grant/research support from Mediquest Therapeutics.
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Herrick, A. A local approach to Raynaud phenomenon. Nat Rev Rheumatol 5, 246–247 (2009). https://doi.org/10.1038/nrrheum.2009.64
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DOI: https://doi.org/10.1038/nrrheum.2009.64
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