Multimodal dementia prevention — does trial design mask efficacy?

The first large trial of a multimodal lifestyle intervention combined with a nutritional supplement for dementia prevention was unsuccessful and adds to conflicting evidence from similar studies. Whether lifestyle interventions are biologically ineffective or whether the lack of efficacy is due to methodological limitations remains to be determined.

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Correspondence to Nikolaos Scarmeas.

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The author declares no competing financial interests.

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Scarmeas, N. Multimodal dementia prevention — does trial design mask efficacy?. Nat Rev Neurol 13, 322–323 (2017).

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