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Dementia

Multimodal dementia prevention — does trial design mask efficacy?

Nature Reviews Neurology volume 13, pages 322–323 (2017)Cite this article

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The first large trial of a multimodal lifestyle intervention combined with a nutritional supplement for dementia prevention was unsuccessful and adds to conflicting evidence from similar studies. Whether lifestyle interventions are biologically ineffective or whether the lack of efficacy is due to methodological limitations remains to be determined.

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References

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Authors and Affiliations

  1. Nikolaos Scarmeas is at the Department of Social Medicine, Department of Neurology, Psychiatry and Neurology, National and Kapodistrian University of Athens, 72 Vasilisis Sofias Avenue, Athens, 11528, Greece, and the Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University Medical Center, Sergievsky Center, 622 West 168th Street, PH 19th Floor, New York, New York 10032, USA.,

    Nikolaos Scarmeas

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  1. Nikolaos Scarmeas
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Correspondence to Nikolaos Scarmeas.

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The author declares no competing financial interests.

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Scarmeas, N. Multimodal dementia prevention — does trial design mask efficacy?. Nat Rev Neurol 13, 322–323 (2017). https://doi.org/10.1038/nrneurol.2017.73

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