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Long-term outcomes in MRI-negative patients with epilepsy

Patients with drug-resistant focal epilepsy who lack structural abnormalities on MRI constitute a challenge in presurgical work-up. A longitudinal single-centre study of long-term seizure outcomes in patients with nonlesional epilepsy showed that 59% of the cohort was free from disabling seizures 10 years after resective epilepsy surgery. These results are encouraging and valuable for patient counselling.

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  1. de Tisi, J. et al. The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study. Lancet 378, 1388–1395 (2011).

    Article  Google Scholar 

  2. Edelvik, A. et al. Long-term outcomes of epilepsy surgery in Sweden: a national prospective and longitudinal study. Neurology 81, 1244–1251 (2013).

    Article  Google Scholar 

  3. Bjellvi, J., Flink, R., Rydenhag, B. & Malmgren, K. Complications of epilepsy surgery in Sweden 1996–2010: a prospective, population-based study. J. Neurosurg. 122, 519–525 (2015).

    Article  Google Scholar 

  4. Malmgren, K., Baxendale, S. & Helen Cross, J. (eds) Long-term outcomes of epilepsy surgery in adults and children (Springer International Publishing Switzerland, 2015).

    Book  Google Scholar 

  5. Cloppenborg, T. et al. Trends in epilepsy surgery: stable surgical numbers despite increasing presurgical volumes. J. Neurol. Neurosurg. Psychiatry 87, 1322–1329 (2016).

    Article  Google Scholar 

  6. Kim, D. W. et al. Surgical treatment of nonlesional neocortical epilepsy: long-term longitudinal study. JAMA Neurol. (2017).

  7. Beghi, E. & Tonini, C. Surgery for epilepsy: assessing evidence from observational studies. Epilepsy Res. 70, 97–102 (2006).

    Article  Google Scholar 

  8. Engel, J., Van Ness, P. C., Rasmussen, T. B. & Ojemann, L. M. in Surgical treatment of the epilepsies (ed. Engel, J.) 609–621 (Raven Press Ltd., 1993).

    Google Scholar 

  9. Wieser, H. G. et al. ILAE Commission Report. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery. Epilepsia 42, 282–286 (2001).

    Article  CAS  Google Scholar 

  10. Bourdillon, P. et al. Stereo electroencephalography-guided radiofrequency thermocoagulation (SEEG-guided RF-TC) in drug-resistant focal epilepsy: results from a 10-year experience. Epilepsia 58, 85–93 (2017).

    Article  Google Scholar 

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Correspondence to Kristina Malmgren.

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The authors declare no competing financial interests.

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Malmgren, K., Krýsl, D. Long-term outcomes in MRI-negative patients with epilepsy. Nat Rev Neurol 13, 132–133 (2017).

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