Two studies have shown no added benefit of intravenous thrombolysis in patients with acute stroke who are treated with mechanical thrombectomy. We review the importance and interpretation of these findings, compare them to the current guidelines on stroke thrombectomy, and discuss how these studies can change our daily clinical practice.
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E.I.L. has shareholder/ownership interests in Blockade Medical, Intratech Medical and NeXtGen Biologics. He serves as a national principal investigator for the Covidien US SWIFT PRIME Trials and receives honoraria for training and lecturing from Covidien. He receives compensation from Abbott for carotid training sessions for physicians. He serves as a consultant to Pulsar and Blockade Medical and on the Acute Ischemic Stroke Clinical Advisory Board for Stryker and the Advisory Board for NeXtGen Biologics and MEDX. M.M. declares no competing interests.
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Levy, E., Mokin, M. Stroke thrombolysis and thrombectomy—not stronger together?. Nat Rev Neurol 13, 198–200 (2017). https://doi.org/10.1038/nrneurol.2017.22
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DOI: https://doi.org/10.1038/nrneurol.2017.22
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