Stroke in 2017

Intensive and extensive — advances in stroke management

The past year saw advances in endovascular treatment for acute stroke, speech therapy for aphasia after stroke, and cardiac disease management to prevent stroke. These treatments were characterized by more intensive or more extensive effects than standard care, necessitating thoughtful translation of the clinical trial findings into routine clinical practice.

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  1. 1

    van den Berg, L. A. et al. Two-year outcome after endovascular treatment for acute ischemic stroke. N. Engl. J. Med. 376, 1341–1349 (2017).

    Article  Google Scholar 

  2. 2

    Nogueira, R. G. et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N. Engl. J. Med. (2017).

  3. 3

    Mas, J. L. et al. Patent foramen ovale closure or anticoagulation versus antiplatelets after stroke. N. Engl. J. Med. 377, 1011–1021 (2017).

    CAS  Article  Google Scholar 

  4. 4

    Søndergaard, L. et al. Patent foramen ovale closure or antiplatelet therapy for cryptogenic stroke. N. Engl. J. Med. 377, 1033–1042 (2017).

    Article  Google Scholar 

  5. 5

    Saver, J. L. et al. Long-term outcomes of patent foramen ovale closure or medical therapy after stroke. N. Engl. J. Med. 377, 1022–1032 (2017).

    Article  Google Scholar 

  6. 6

    De Caterina, R. et al. Valvular heart disease patients on edoxaban or warfarin in the ENGAGE AF–TMI 48 trial. J. Am. Coll. Cardiol. 69, 1372–1382 (2017).

    CAS  Article  Google Scholar 

  7. 7

    Pan, K. L. et al. Effects of non-vitamin K antagonist oral anticoagulants versus warfarin in patients with atrial fibrillation and valvular heart disease: a systematic review and meta-analysis. J. Am. Heart Assoc. 6, e005835 (2017).

    PubMed  PubMed Central  Google Scholar 

  8. 8

    Breitenstein, C. et al. Intensive speech and language therapy in patients with chronic aphasia after stroke: a randomised, open-label, blinded-endpoint, controlled trial in a health-care setting. Lancet 389, 1528–1538 (2017).

    Article  Google Scholar 

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Correspondence to Bruce Ovbiagele.

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The authors declare no competing financial interests.

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Lee, M., Ovbiagele, B. Intensive and extensive — advances in stroke management. Nat Rev Neurol 14, 68–70 (2018).

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