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Parkinson disease in 2017

Changing views after 200 years of Parkinson disease

200 years after James Parkinson's An Essay on the Shaking Palsy, 2017 has seen important advances that are driving a shift towards a broader and more holistic understanding of Parkinson disease aetiology and progression. This shift might finally pave the way to entirely novel and more effective prevention and management strategies.

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Figure 1: Precision medicine in Parkinson disease.

References

  1. Obeso, J. A. et al. Past, present, and future of Parkinson's disease: a special essay on the 200th anniversary of the Shaking Palsy. Mov. Disord. 32, 1264–1310 (2017).

    Article  CAS  Google Scholar 

  2. Espay, A. J. et al. Biomarker-driven phenotyping in Parkinson's disease: a translational missing link in disease-modifying clinical trials. Mov. Disord. 32, 319–324 (2017).

    Article  Google Scholar 

  3. Mass, E. et al. A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease. Nature 549, 389–393 (2017).

    Article  CAS  Google Scholar 

  4. Witoelar, A. et al. Genome-wide pleiotropy between Parkinson disease and autoimmune diseases. JAMA Neurol. 74, 780–792 (2017).

    Article  Google Scholar 

  5. Pilotto, A. et al. Application of the movement disorder society prodromal Parkinson's disease research criteria in 2 independent prospective cohorts. Mov. Disord. 32, 1025–1034 (2017).

    Article  CAS  Google Scholar 

  6. Fereshtehnejad, S.-M. et al. Clinical criteria for subtyping Parkinson's disease: biomarkers and longitudinal progression. Brain 140, 1959–1976 (2017).

    Article  Google Scholar 

  7. van Uem, J. et al. Health-related quality of life in patients with Parkinson's disease — a systematic review based on the ICF model. Neurosci. Biobehav. Rev. 61, 26–34 (2016).

    Article  Google Scholar 

  8. Henderson, E. J. et al. Rivastigmine for gait stability in patients with Parkinson's disease (ReSPonD): a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet. Neurol. 15, 249–258 (2016).

    Article  CAS  Google Scholar 

  9. Nieuwhof, F. et al. Impaired dual tasking in Parkinson's disease is associated with reduced focusing of cortico-striatal activity. Brain 140, 1384–1398 (2017).

    Article  Google Scholar 

  10. Mittal, S. et al. β2-adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease. Science 357, 891–898 (2017).

    Article  CAS  Google Scholar 

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Correspondence to Daniela Berg.

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Maetzler, W., Berg, D. Changing views after 200 years of Parkinson disease. Nat Rev Neurol 14, 70–72 (2018). https://doi.org/10.1038/nrneurol.2017.183

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