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Stroke

Patients with CVT urgently need high-quality evidence

Nature Reviews Neurology volume 13, pages 644–646 (2017)Cite this article

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In recently published guidelines on the diagnosis and treatment of cerebral venous thrombosis, the European Stroke Organization has applied a rigorous evidence-based methodology, following the GRADE system. However, the guidelines provide many weak recommendations, reflecting the fact that more high-quality evidence from multicentre observational and experimental studies is needed.

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References

  1. Stam, J. Thrombosis of the cerebral veins and sinuses. N. Engl. J. Med. 352, 1791–1798 (2005).

    Article  CAS  Google Scholar 

  2. Dentali, F. et al. Natural history of cerebral vein thrombosis: a systematic review. Blood 108, 1129–1134 (2006).

    Article  CAS  Google Scholar 

  3. Saposnik, G. et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 42, 1158–1192 (2011).

    Article  Google Scholar 

  4. Dentali, F. et al. Long-term outcomes of patients with cerebral vein thrombosis: a multicenter study. J. Thromb. Haemost. 10, 1297–1302 (2012).

    Article  CAS  Google Scholar 

  5. Ferro, J. M. et al. European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis — endorsed by the European Academy of Neurology. Eur. J. Neurol. 24, 1203–1213 (2017).

    Article  CAS  Google Scholar 

  6. Einhäupl, K. et al. EFNS guideline on the treatment of cerebral venous and sinus thrombosis in adult patients. Eur. J. Neurol. 17, 1229–1235 (2010).

    Article  Google Scholar 

  7. Guyatt, G. H. et al. GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J. Clin. Epidemiol. 64, 380–382 (2011).

    Article  Google Scholar 

  8. Guyatt, G. et al. A guide to GRADE guidelines for the readers of JTH. J. Thromb. Haemost. 11, 1603–1608 (2013).

    Article  CAS  Google Scholar 

  9. Guyatt, G. H. et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336, 924–926 (2008).

    Article  Google Scholar 

  10. Qureshi, A. & Perera, A. Low molecular weight heparin versus unfractionated heparin in the management of cerebral venous thrombosis: a systematic review and meta-analysis. Ann. Med. Surg. (Lond.) 17, 22–26 (2017).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Nicoletta Riva is at the Department of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, MSD 2080, Malta.,

    Nicoletta Riva

  2. Department of Medicine and Surgery, Alessandro Squizzato is at the Research Center on Thromboembolic Disorders and Antithrombotic Therapies, University of Insubria, U.O. Medicina 1, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy.,

    Alessandro Squizzato

Authors
  1. Nicoletta Riva
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  2. Alessandro Squizzato
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Correspondence to Alessandro Squizzato.

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The authors declare no competing financial interests.

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Riva, N., Squizzato, A. Patients with CVT urgently need high-quality evidence. Nat Rev Neurol 13, 644–646 (2017). https://doi.org/10.1038/nrneurol.2017.143

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