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Multiple sclerosis

Fingolimod failure in progressive MS INFORMS future trials

Fingolimod is approved for the treatment of relapsing–remitting multiple sclerosis (MS), and evidence suggests that it has neuroprotective effects. The recent INFORMS phase III trial in primary progressive MS demonstrated no beneficial effects of fingolimod on disability progression or whole-brain atrophy, but provides important information for future therapeutic development.

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Acknowledgements

A.L.S. is supported by a National Multiple Sclerosis Society Sylvia Lawry Physician Fellowship Award (FP 17117-A-2).

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Correspondence to Jeffrey A. Cohen.

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Competing interests

A.L.S. has received speaking fees from Genzyme. J.A.C. has received personal compensation for consulting for Genentech, Genzyme, Novartis and Receptos, and speaking fees from Teva.

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Smith, A., Cohen, J. Fingolimod failure in progressive MS INFORMS future trials. Nat Rev Neurol 12, 253–254 (2016). https://doi.org/10.1038/nrneurol.2016.37

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