Movement disorders in 2016

Progress in Parkinson disease and other movement disorders

In the field of movement disorders, areas that have seen important advances in 2016 include the pathogenesis of Parkinson disease involving extra-CNS α-synuclein pathology, treatment of hyperkinetic disorders with novel dopamine-depleting drugs, and MRI-guided ultrasound surgery for the treatment of essential tremor.

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Figure 1: Mechanism of action of VMAT2 inhibitors.


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Correspondence to Joseph Jankovic.

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Competing interests

J.J. has received research and/or training grants from the Michael J. Fox Foundation for Parkinson Research, the NIH, Neurocrine Biosciences, Prothena Biosciences and Teva Pharmaceuticals. He has served as a consultant or as an advisory committee member for Allergan, Pfizer and Teva Pharmaceuticals.

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Jankovic, J. Progress in Parkinson disease and other movement disorders. Nat Rev Neurol 13, 76–78 (2017).

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