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Neuroendocrinology

Oestrogen therapy affects brain structure but not function

Nature Reviews Neurology volume 12, pages 561–562 (2016)Cite this article

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According to new research, oestrogen therapy in postmenopausal women is associated with ventricular enlargement and increased white matter hyperintensities in the brain, but not with cognitive decline. This disconnect between structural and functional effects suggests that brain-derived lipids can be harnessed to meet the bioenergetic demand imposed by normal cognition.

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Authors and Affiliations

  1. Roberta Brinton is at the University of Arizona Center for Innovation in Brain Science, College of Medicine, 1501 North Campbell Avenue, P.O. BOX 245126, Tucson, Arizona 85724-5126, USA.,

    Roberta Diaz Brinton

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  1. Roberta Diaz Brinton
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Correspondence to Roberta Diaz Brinton.

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Brinton, R. Oestrogen therapy affects brain structure but not function. Nat Rev Neurol 12, 561–562 (2016). https://doi.org/10.1038/nrneurol.2016.147

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