According to a recent study, a high percentage of children with epilepsy show comorbid somatic, neurological, and developmental or psychiatric disorders. To provide comprehensive care for paediatric patients with epilepsy, all their needs must be evaluated and managed, including careful consideration of comorbid disorders.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Aaberg, K. M. et al. Comorbidity and chilhood epilepsy: a nationwide registry study. Pediatrics 138 e20160921 (2016).
Lin, J. J., Mula, M. & Hermann, B. P. Uncovering the neurobehavioral comorbidities of epilepsy over the lifespan. Lancet 380, 1180–1192 (2012).
Gaitatzis, A., Sisodiya, S. M. & Sander, J. W. The somatic comorbidity of epilepsy: a weighty but often unrecognized burden. Epilepsia 53, 1282–1293 (2012).
Berg, A. T. et al. Psychiatric and neurodevelopmental disorders in childhood-onset epilepsy. Epilepsy Behav. 20, 550–555 (2011).
Baca, C. B., Vickrey, B. G., Caplan, R., Vassar, S. D. & Berg, A. T. Psychiatric and medical comorbidity and quality of life outcomes in childhood-onset epilepsy. Pediatrics 128, e1532–e1543 (2011).
Reilly, C. et al. Neurobehavioral comorbidities in children with active epilepsy: a population-based-study. Pediatrics 133, e1586–e1593 (2014).
Veliog˘lu, S. K., Boz, C. & Ozmenog˘lu, M. The impact of migraine on epilepsy: a prospective prognosis study. Cephalalgia 25, 528–535 (2005).
Nickels, K. C., Zaccariello, M. J., Hamiwka, L. D. & Wirrell, E. C. Cognitive and neurodevelopmental comorbidities in paediatric epilepsy. Nat. Rev. Neurol. 12, 465–476 (2016).
Arya, R. et al. Obesity and overwhight as CAE comorbidities and differential drug response modifiers. Neurology 26, 1613–1621 (2016).
Stores, G. Sleep disturbance in childhood epilepsy: clinical implications, assessment and treatment. Arch. Dis. Child. 98, 548–551 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Verrotti, A., Mazzocchetti, C. Beyond seizures — the importance of comorbidities in epilepsy. Nat Rev Neurol 12, 559–560 (2016). https://doi.org/10.1038/nrneurol.2016.135
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2016.135
This article is cited by
-
SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients
European Journal of Clinical Pharmacology (2019)
