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Migraine

Treasure hunt in a minefield — exploring migraine with GWAS

Nature Reviews Neurology volume 12, pages 496–498 (2016)Cite this article

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In a powerful display of international collaboration, a new genome-wide association study has mapped susceptibility loci for migraine on the basis of genetic data from 375,000 individuals. The study implicates several new loci in migraine — many of them suggestive of vascular pathophysiology — but the functional relevance of many now-detected risk alleles remains elusive.

Refers to Gormley, P. et al. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat. Genet. 48, 856–866 (2016)

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Acknowledgements

C.A. has received support from the National Institutes of Health (grants NS061505, NS055104, and NS35611), Fondation Leducq, The Heitman Foundation and The Ellison Foundation.

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  1. Departments of Radiology and Neurology, Cenk Ayata is at Neurovascular Research Laboratory, Massachusetts General Hospital and Harvard Medical School, 149 13th street, Charlestown, Massachusetts 02129, USA.,

    Cenk Ayata

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  1. Cenk Ayata
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Correspondence to Cenk Ayata.

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Ayata, C. Treasure hunt in a minefield — exploring migraine with GWAS. Nat Rev Neurol 12, 496–498 (2016). https://doi.org/10.1038/nrneurol.2016.118

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  • DOI: https://doi.org/10.1038/nrneurol.2016.118

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