In a powerful display of international collaboration, a new genome-wide association study has mapped susceptibility loci for migraine on the basis of genetic data from 375,000 individuals. The study implicates several new loci in migraine — many of them suggestive of vascular pathophysiology — but the functional relevance of many now-detected risk alleles remains elusive.
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C.A. has received support from the National Institutes of Health (grants NS061505, NS055104, and NS35611), Fondation Leducq, The Heitman Foundation and The Ellison Foundation.
The author declares no competing financial interests.
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Ayata, C. Treasure hunt in a minefield — exploring migraine with GWAS. Nat Rev Neurol 12, 496–498 (2016). https://doi.org/10.1038/nrneurol.2016.118
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