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Multiple sclerosis

Dimethyl fumarate is coming of age

Nature Reviews Neurology volume 12, pages 436–437 (2016)Cite this article

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Recently published findings from the ENDORSE study provide 5 years of randomized safety and efficacy data for two doses of dimethyl fumarate (DMF) in multiple sclerosis. The report complements results from the pivotal CONFIRM and DEFINE trials; however, postmarketing data from clinical practice is needed to complete the risk–benefit profile of DMF.

Refers to Gold, R. et al. Long-term effects of delayed-release dimethyl fumarate in multiple sclerosis: interim analysis of ENDORSE, a randomized extension study. Mult. Scler. (2016)

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Authors and Affiliations

  1. Department of Neurology/Neuroimmunology, Jaume Sastre-Garriga and Mar Tintoré are at the Centre d'Esclerosi Múltiple de Catalunya, Hospital Universitari Vall d'Hebron, Passeig Vall d'Hebron 119–129, Universitat Autònoma de Barcelona, Barcelona 08035, Spain.,

    Mar Tintoré & Jaume Sastre-Garriga

Authors
  1. Mar Tintoré
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  2. Jaume Sastre-Garriga
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Both authors research literature for the article, and provided substantial contribution to discussion of content, writing and editing of the manuscript.

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Correspondence to Mar Tintoré.

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Competing interests

J.S.-G. has received compensation for consulting services and speaking honoraria from Biogen-Idec, Merck-Serono, Novartis and Teva. M.T. has received compensation for consulting services and speaking honoraria from Almirall, Bayer-Schering, Biogen-Idec, Genzyme, Merck-Serono, Novartis, Roche, Sanofi and Teva.

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Tintoré, M., Sastre-Garriga, J. Dimethyl fumarate is coming of age. Nat Rev Neurol 12, 436–437 (2016). https://doi.org/10.1038/nrneurol.2016.106

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  • DOI: https://doi.org/10.1038/nrneurol.2016.106

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