Recently published findings from the ENDORSE study provide 5 years of randomized safety and efficacy data for two doses of dimethyl fumarate (DMF) in multiple sclerosis. The report complements results from the pivotal CONFIRM and DEFINE trials; however, postmarketing data from clinical practice is needed to complete the risk–benefit profile of DMF.
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J.S.-G. has received compensation for consulting services and speaking honoraria from Biogen-Idec, Merck-Serono, Novartis and Teva. M.T. has received compensation for consulting services and speaking honoraria from Almirall, Bayer-Schering, Biogen-Idec, Genzyme, Merck-Serono, Novartis, Roche, Sanofi and Teva.
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Tintoré, M., Sastre-Garriga, J. Dimethyl fumarate is coming of age. Nat Rev Neurol 12, 436–437 (2016). https://doi.org/10.1038/nrneurol.2016.106
Nature Reviews Neurology (2019)