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Alzheimer disease

Host immune defence, amyloid-β peptide and Alzheimer disease

Nature Reviews Neurology volume 12, pages 433434 (2016) | Download Citation

A recent study demonstrates that amyloid-β (Aβ) can function as an antimicrobial peptide, and additional data show that bacteria and yeast can seed Aβ deposition into amyloid. These data suggest a complex interplay between the normal function of Aβ, its accumulation in the brain, and host immune defence.

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References

  1. 1.

    et al. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease. Sci. Transl. Med. 8, 340ra372 (2016).

  2. 2.

    The pathogenesis of Alzheimer's disease and the role of Aβ42. CNS Spectr. 12 (Suppl. 1), 4–6 (2007).

  3. 3.

    , & The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat. Rev. Neurol. 6, 99–107 (2010).

  4. 4.

    et al. The Alzheimer's disease-associated amyloid β-protein is an antimicrobial peptide. PLoS ONE 5, e9505 (2010).

  5. 5.

    et al. Antimicrobial properties of amyloid peptides. Mol. Pharm. 9, 708–717 (2012).

  6. 6.

    et al. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol. Commun. 3, 72 (2015).

  7. 7.

    & Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann. Neurol. 70, 532–540 (2011).

  8. 8.

    et al. Microbes and Alzheimer's disease. J. Alzheimers Dis. 51, 979–984 (2016).

  9. 9.

    , & Innate immunity in Alzheimer's disease. Nat. Immunol. 16, 229–236 (2015).

  10. 10.

    Alzheimer disease: TREM2 linked to late-onset AD. Nat. Rev. Neurol. 9, 5 (2012).

Download references

Author information

Affiliations

  1. Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brian Institute, College of Medicine, University of Florida, 1275 Center Drive, BMS J-497, Gainesville, Florida 32610, USA.

    • Todd E. Golde

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Todd E. Golde.

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DOI

https://doi.org/10.1038/nrneurol.2016.105

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