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Alzheimer disease

Host immune defence, amyloid-β peptide and Alzheimer disease

A recent study demonstrates that amyloid-β (Aβ) can function as an antimicrobial peptide, and additional data show that bacteria and yeast can seed Aβ deposition into amyloid. These data suggest a complex interplay between the normal function of Aβ, its accumulation in the brain, and host immune defence.

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Figure 1: Antimicrobial peptide activity of amyloid-β.


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Correspondence to Todd E. Golde.

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Golde, T. Host immune defence, amyloid-β peptide and Alzheimer disease. Nat Rev Neurol 12, 433–434 (2016).

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