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Alzheimer disease

Host immune defence, amyloid-β peptide and Alzheimer disease

A recent study demonstrates that amyloid-β (Aβ) can function as an antimicrobial peptide, and additional data show that bacteria and yeast can seed Aβ deposition into amyloid. These data suggest a complex interplay between the normal function of Aβ, its accumulation in the brain, and host immune defence.

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Figure 1: Antimicrobial peptide activity of amyloid-β.

References

  1. Kumar, D. K. et al. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease. Sci. Transl. Med. 8, 340ra372 (2016).

    Article  Google Scholar 

  2. Golde, T. E. The pathogenesis of Alzheimer's disease and the role of Aβ42. CNS Spectr. 12 (Suppl. 1), 4–6 (2007).

    Article  Google Scholar 

  3. De Strooper, B., Vassar, R. & Golde, T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat. Rev. Neurol. 6, 99–107 (2010).

    Article  CAS  Google Scholar 

  4. Soscia, S. J. et al. The Alzheimer's disease-associated amyloid β-protein is an antimicrobial peptide. PLoS ONE 5, e9505 (2010).

    Article  Google Scholar 

  5. Kagan, B. L. et al. Antimicrobial properties of amyloid peptides. Mol. Pharm. 9, 708–717 (2012).

    Article  CAS  Google Scholar 

  6. Xu, G. et al. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol. Commun. 3, 72 (2015).

    Article  Google Scholar 

  7. Jucker, M. & Walker, L. C. Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann. Neurol. 70, 532–540 (2011).

    Article  CAS  Google Scholar 

  8. Itzhaki, R. F. et al. Microbes and Alzheimer's disease. J. Alzheimers Dis. 51, 979–984 (2016).

    Article  Google Scholar 

  9. Heneka, M. T., Golenbock, D. T. & Latz, E. Innate immunity in Alzheimer's disease. Nat. Immunol. 16, 229–236 (2015).

    Article  CAS  Google Scholar 

  10. Jones, B. Alzheimer disease: TREM2 linked to late-onset AD. Nat. Rev. Neurol. 9, 5 (2012).

    Article  Google Scholar 

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Correspondence to Todd E. Golde.

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Golde, T. Host immune defence, amyloid-β peptide and Alzheimer disease. Nat Rev Neurol 12, 433–434 (2016). https://doi.org/10.1038/nrneurol.2016.105

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  • DOI: https://doi.org/10.1038/nrneurol.2016.105

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