Local synthesis of IgG in the CNS is present in >90% of patients with multiple sclerosis (MS), and is considered a hallmark of the disease. A recent study has discovered genetic factors associated with intrathecal production of these antibodies, and suggests excessive IgG synthesis as an indicator of an aggressive disease.
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J.C.Á.-C. has received honoraria for speaking or consultancy, or support for research from Almirall, Bayer-Schering, Biogen Idec, Genzyme, Merck Serono, Novartis, Roche, and Teva. L.M.V. has received honoraria for speaking or consultancy, or support for research from Bayer-Schering, Biogen Idec, Binding Site, Genzyme, Merck Serono, Novartis, and Teva.
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Álvarez-Cermeño, J., Villar, L. Genetic variability affects CNS IgG production in MS. Nat Rev Neurol 11, 313–314 (2015). https://doi.org/10.1038/nrneurol.2015.55
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DOI: https://doi.org/10.1038/nrneurol.2015.55
