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The rising global tide of cognitive impairment

A new study suggests that the application of uniform diagnostic criteria for mild cognitive impairment (MCI) substantially reduces variation in MCI prevalence estimates. Refinement and harmonization of clinical and research criteria are essential milestones towards improved testing of therapeutic interventions aimed at curbing the epidemic of MCI and dementia.

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Figure 1: Hypothetical staging model of sporadic Alzheimer disease (AD).


  1. Petersen, R. C. et al. Mild cognitive impairment: a concept in evolution. J. Intern. Med. 275, 214–228 (2014).

    Article  CAS  Google Scholar 

  2. Sachdev, P. S. et al. The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC collaboration. PLoS ONE 10, e0142388 (2015).

    Article  Google Scholar 

  3. Sachdev, P. S. et al. COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. BMC Neurol. 13, 165 (2013).

    Article  Google Scholar 

  4. Prince, M. et al. The global prevalence of dementia: a systematic review and meta-analysis. Alzheimers Dement. 9, 63–75. e2 (2013).

    Article  Google Scholar 

  5. Dubois, B. et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol. 13, 614–629 (2014).

    Article  Google Scholar 

  6. Albert, M. S. et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 7, 270–279 (2011).

    Article  Google Scholar 

  7. Schneider, L. S. The potential and limits for clinical trials for early Alzheimer's disease and some recommendations. J. Nutr. Health Aging 14, 295–298 (2010).

    Article  CAS  Google Scholar 

  8. Norton, S., Matthews, F. E., Barnes, D. E., Yaffe, K. & Brayne, C. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol. 13, 788–794 (2014).

    Article  Google Scholar 

  9. Jagger, C. et al. A comparison of health expectancies over two decades in England: results of the Cognitive Function and Ageing Study I and II. Lancet 382, 1405–1452 (2015).

    Google Scholar 

  10. Solomon, A. et al. Advances in the prevention of Alzheimer's disease and dementia. J. Intern. Med. 275, 229–250 (2014).

    Article  CAS  Google Scholar 

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H.H. is supported by the AXA Research Fund, the Fondation Université Pierre et Marie Curie, the “Fondation pour la Recherche sur Alzheimer”, Paris, France, and the programme “Investissements d'avenir” (programme number ANR-10-IAIHU-06).

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Correspondence to Harald Hampel.

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H.H. has received lecture honoraria from Biogen and Roche, research grants from Avid and Pfizer, travel funding from Axovant, Eli Lilly and company, GE Healthcare, Takeda and Zinfandel, consultancy fees from Anavex, Axovant, Cytox, GE Healthcare, Jung diagnostics, Takeda and Zinfandel, and participated in scientific advisory boards of Axovant, Cytox, GE Healthcare, Takeda and Zinfandel. He is co-inventor in (partly pending) patent submissions for which he has received no royalties. S.L. has received lecture honoraria from Roche.

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Hampel, H., Lista, S. The rising global tide of cognitive impairment. Nat Rev Neurol 12, 131–132 (2016).

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