Cognitive impairment is a major sequela after stroke. A recent study shows that cognitive impairment is prevalent after ischaemic stroke, even in patients with good functional recovery, and that compromise in different cognitive domains predicts future functional disability. Here, we reflect on how poststroke cognitive impairment is measured and conceptualized.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Jokinen, H. et al. Post-stroke cognitive impairment is common even after successful clinical recovery. Eur. J. Neurol. http://dx.doi.org/10.1111/ene.12743.
Godefroy, O. et al. Validation of an integrated method for determining cognitive ability: implications for routine assessments and clinical trials. Cortex 54, 51–62 (2014).
Farias, S. T., Harrell, E., Neumann, C. & Houtz, A. The relationship between neuropsychological performance and daily functioning in individuals with Alzheimer's disease: ecological validity of neuropsychological tests. Arch. Clin. Neuropsychol. 18, 655–672 (2003).
Morris, J. C. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43, 2412–2414 (1993).
Cedarbaum, J. M. et al. Rationale for use of the Clinical Dementia Rating Sum of Boxes as a primary outcome measure for Alzheimer's disease clinical trials. Alzheimers Dement. 9 (1 Suppl.), S45–S55 (2013).
Yang, J. et al. Risk factors for incident dementia after stroke and transient ischemic attack. Alzheimers Dement. 11, 16–23 (2015).
Sperling, R. & Johnson, K. Biomarkers of Alzheimer disease: current and future applications to diagnostic criteria. Continuum (Minneap. Minn.) 19, 325–338 (2013).
Hachinski, V. et al. National Institute of Neurological Disorders and Stroke–Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke 37, 2220–2241 (2006).
Amodio, D. M. & Frith, C. D. Meeting of minds: the medial frontal cortex and social cognition. Nat. Rev. Neurosci. 7, 268–277 (2006).
Darby, D. G. et al. Intraindividual cognitive decline using a brief computerized cognitive screening test. Alzheimers Dement. 8, 95–104 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Wong, A., Mok, V. Poststroke cognitive impairment—what are we measuring?. Nat Rev Neurol 11, 487–488 (2015). https://doi.org/10.1038/nrneurol.2015.130
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2015.130
