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Multiple sclerosis

Does aggressive MS warrant aggressive treatment?

Aggressive, refractory multiple sclerosis warrants unconventional therapy. A retrospective multicentre study assessed the effects of ablating the immune system, then reconstituting it using bone marrow derived stem cells. Though this particular regimen improved disability in some patients, others continued to relapse, perhaps indicating the treatment did not go far enough.

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References

  1. Pfender, N., Saccardi, R. & Martin, R. Autologous hematopoietic stem cell transplantation as a treatment option for aggressive multiple sclerosis. Curr. Treat. Options Neurol. 15, 270–280 (2013).

    Article  PubMed  Google Scholar 

  2. Burman, J. et al. Autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: the Swedish experience. J. Neurol. Neurosurg. Psychiatry http://dx.doi.org/10.1136/jnnp-2013-307207.

  3. Edan, G. et al. Mitoxantrone prior to interferon beta-1b in aggressive relapsing multiple sclerosis: a 3-year randomised trial. J. Neurol. Neurosurg. Psychiatry 12, 1344–1350 (2011).

    Article  Google Scholar 

  4. Weiner, H. L. Immunosuppressive treatment in multiple sclerosis. J. Neurol. Sci. 223, 1–11 (2004).

    Article  CAS  PubMed  Google Scholar 

  5. Coles, A. J. et al. Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. Lancet 380, 1829–1839 (2012).

    Article  CAS  PubMed  Google Scholar 

  6. Freedman, M. S. 'Time is brain' also in multiple sclerosis. Mult. Scler. 15, 1133–1134 (2009).

    Article  PubMed  Google Scholar 

  7. Scalfari, A. et al. The natural history of multiple sclerosis, a geographically based study 10: relapses and long-term disability. Brain 133, 1914–1929 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Freedman, M. S. et al. Treatment optimization in MS: Canadian MS Working Group updated recommendations. Can. J. Neurol. Sci. 40, 307–323 (2013).

    Article  PubMed  Google Scholar 

  9. Menon, S. et al. Characterising aggressive multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 84, 1192–1198 (2013).

    Article  PubMed  Google Scholar 

Download references

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Correspondence to Mark S. Freedman.

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Freedman, M. Does aggressive MS warrant aggressive treatment?. Nat Rev Neurol 10, 368–370 (2014). https://doi.org/10.1038/nrneurol.2014.98

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