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Multiple sclerosis

Natalizumab to fingolimod—the washout whitewash

A recent multicentre study has assessed the risk of relapse in patients with multiple sclerosis who switched from natalizumab to fingolimod treatment. Despite such efforts, no effective exit strategy from natalizumab treatment has yet been demonstrated for these patients.

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Figure 1: Biological effects of natalizumab and fingolimod.


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Correspondence to Olaf Stüve.

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Competing interests

M.S. has received honoraria or consultancy payments from Bayer Healthcare, Biogen Idec, Baxter, CSL Behring, Grifols, Merck-Serono, Novartis, Sanofi-Aventis, and Teva. His institution has received research support from Bayer Healthcare, Biogen Idec, Merck-Serono, Novartis, and Teva. O.S. declares no competing interests.

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Stangel, M., Stüve, O. Natalizumab to fingolimod—the washout whitewash. Nat Rev Neurol 10, 311–313 (2014).

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