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Dementia in 2014

Towards early diagnosis in Alzheimer disease

Improved neuroimaging and molecular markers of Alzheimer disease (AD) have aided diagnosis of AD in the very early stages, and have facilitated differential diagnosis between AD and other neurodegenerative disorders with dementia. The finding that some older individuals can show amyloid-β pathology while remaining cognitively intact raises important questions regarding prevention strategies.

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Figure 1: Factors contributing to AD pathology.


  1. Dubois, B. et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol. 13, 614–629 (2014).

    Article  Google Scholar 

  2. Bentzinger, T. L. et al. Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proc. Natl Acad. Sci. USA 110, E4502–E4509 (2013).

    Article  Google Scholar 

  3. Norton, S. et al. Potential for primary prevention of Alzheimer's disease-an analysis of population-based data. Lancet Neurol. 13, 788–794 (2014).

    Article  Google Scholar 

  4. Okamura, N. et al. Non-invasive assessments of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET. Brain 137, 1762–1771 (2014).

    Article  Google Scholar 

  5. Chien, D. T. et al. Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808. J. Alz. Dis. 38, 171–184 (2014).

    Article  Google Scholar 

  6. Maruyama, M. et al. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to controls. Neuron 79, 1094–1098 (2013).

    Article  CAS  Google Scholar 

  7. Fagan, A. M. et al. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Sci. Transl. Med. 5, 226ra30 (2014).

    Article  Google Scholar 

  8. Jack, C. R. et al. Age-specific population frequences of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross-sectional study. Lancet Neurol. 13, 997–1005 (2014).

    Article  Google Scholar 

  9. Crary, J. F. et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol. 128, 755–766 (2014).

    Article  CAS  Google Scholar 

  10. Mormino, E. C. et al. Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals. JAMA Neurol. 71, 1379–1385 (2014).

    Article  Google Scholar 

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Correspondence to Agneta Nordberg.

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The author declares no competing financial interests.

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Nordberg, A. Towards early diagnosis in Alzheimer disease. Nat Rev Neurol 11, 69–70 (2015).

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