Long-term treatment with antiepileptic drugs (AEDs) might have an adverse effect on bone health. Hamed et al. analyzed bone mineral content and markers of bone metabolism in 75 patients with epilepsy (mean duration of AED treatment: 10.57 years) and 40 healthy controls. Patients with epilepsy had an increased risk of osteoporosis and osteopenia of the lumbar spine and femoral neck. Notably, 93% of epilepsy patients, but only 30% of controls, had vitamin D deficiency or insufficiency.