Dopaminergic brain imaging might aid early diagnosis of Parkinson disease (PD), but some patients with mild symptoms show no evidence of dopaminergic dysfunction at baseline, and apparently do not progress. Although some of these patients may have been misdiagnosed, others continue to fulfil PD diagnostic criteria despite normal follow-up brain scans.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hughes, A. J., Daniel, S. E., Kilford, L. & Lees, A. J. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J. Neurol. Neurosurg. Psychiatry 55, 181–184 (1992).
Marek, K. et al. Longitudinal follow-up of SWEDD subjects in the PRECEPT Study. Neurology 82, 1791–1797.
Chaudhuri, K. R. et al. Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol. 5, 235–245 (2006).
Mollenhauer, B. et al. Non-motor and diagnostic findings in subjects with de novo Parkinson disease of the DeNoPa cohort. Neurology 81, 1226–1234 (2013).
Berg, D. et al. Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease. Mov. Disord. 29, 454–462 (2014).
Antonini, A. Imaging for early differential diagnosis of parkinsonism. Lancet Neurol. 9, 130–131 (2010).
Scherfler, C. et al. Role of DAT-SPECT in the diagnostic work up of parkinsonism. Mov. Disord. 22, 1229–1238 (2007).
Antonini, A. et al. Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease. Brain 120, 2187–2195 (1997).
Bajaj, N. P. et al. Accuracy of clinical diagnosis in tremulous parkinsonian patients: a blinded video study. J. Neurol. Neurosurg. Psychiatry 81, 1223–1228 (2010).
Berardelli, A. et al. EFNS/MDS-ES recommendations for the diagnosis of Parkinson's disease. Eur. J. Neurol. 20, 16–34 (2013).
Acknowledgements
R.B. was supported by the Italian National research grant N: RF-2009-153017
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Antonini, A., Biundo, R. Can dopamine transporter imaging define early PD?. Nat Rev Neurol 10, 432–433 (2014). https://doi.org/10.1038/nrneurol.2014.123
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2014.123
