Discovery of the endogenous cannabinoid signalling system unleashed substantial new research into several neurological conditions. A recent systematic review suggests that medical marijuana can improve a number of symptoms—particularly spasticity—in multiple sclerosis, but cannabinoids can have adverse psychological effects and their comparative effectiveness is unknown.
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J.Z. has received funding to conduct studies of cannabinoids in multiple sclerosis from the UK Medical Research Council.
J.Z. has received funding from the Institut für klinische Forschung, Berlin, which manufactures Cannador. R.H. declares no competing interests.
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Hosking, R., Zajicek, J. Cannabis in neurology—a potted review. Nat Rev Neurol 10, 429–430 (2014). https://doi.org/10.1038/nrneurol.2014.122