In relapsing–remitting multiple sclerosis, conversion to the progressive stage is thought to be influenced by early relapses. Despite a new study suggesting that relapses do not drive long-term disability and proposing the latency period as an ideal target for therapeutic intervention, the relapsing phase remains a relevant treatment window.
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References
Tremlett, H. et al. Impact of multiple sclerosis relapses on progression diminishes with time. Neurology 9, 309–317 (2009).
Scalfari, A. et al. The natural history of multiple sclerosis: a geographically based study 10: relapses and long-term disability. Brain 133, 1914–1929 (2010).
Scalfari, A. et al. Early relapses, onset of progression, and late outcome in multiple sclerosis. Arch. Neurol. http://dx.doi.org/10.1001/jamaneurol.2013.599.
Confavreux, C. & Vukusic, S. Accumulation of irreversible disability in multiple sclerosis: from epidemiology to treatment. Clin. Neurol. Neurosurg. 108, 327–332 (2006).
Confavreux, C. et al. Relapses and progression of disability in multiple sclerosis. N. Engl. J. Med. 343, 1430–1438 (2000).
Lublin, F. D., Baier, M. & Cutter, G. R. Effect of relapses on development of residual deficit in multiple sclerosis. Neurology 61, 1528–1532 (2003).
Lassmann, H., Brück, W. & Lucchinetti, C. Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. Trends Mol. Med. 7, 115–121 (2001).
Wilkins, A. & Scolding, N. Protecting axons in multiple sclerosis. Mult. Scler. 14, 1013–1025 (2008).
Renoux, C. Natural history of multiple sclerosis: long-term prognostic factors. Neurol. Clin. 29, 293–308 (2011).
Pugliatti, M. et al. Assess, compare and enhance the status of Persons with Multiple Sclerosis (MS) in Europe: a European Register for MS. Acta Neurol. Scand. Suppl. 126, 24–30 (2012).
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Pugliatti, M. Preventing progression and disability in MS—when to treat?. Nat Rev Neurol 9, 129–130 (2013). https://doi.org/10.1038/nrneurol.2013.28
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DOI: https://doi.org/10.1038/nrneurol.2013.28