Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Epilepsy in 2013

Progress across the spectrum of epilepsy research


Over the past year, we have witnessed major advances in several areas of epilepsy research, including genetics and disease mechanisms, neurodevelopmental effects of antiepileptic drugs, and new therapeutic approaches based on closed-loop neurostimulator systems. The findings have important implications both for clinical practice and for future research.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Institute of Medicine. Epilepsy across the spectrum: promoting health and understanding. The National Academies Press, Washington, DC [online], (2012).

  2. 2

    Epi4K Consortium & Epilepsy Phenome/Genome Project. De novo mutations in epileptic encephalopathies. Nature 501, 217–221 (2013).

  3. 3

    Ryvlin, P. et al. Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study. Lancet Neurol. 12, 966–977 (2013).

    Article  Google Scholar 

  4. 4

    Sillanpää, M. & Shinnar, S. Long-term mortality in childhood-onset epilepsy. N. Engl. J. Med. 363, 2522–2529 (2010).

    Article  Google Scholar 

  5. 5

    Sowers, L. P., Massey, C. A., Gehlbach, B. K., Granner, M. A. & Richerson, G. B. Sudden unexpected death in epilepsy: fatal post-ictal respiratory and arousal mechanisms. Respir. Physiol. Neurobiol. 189, 315–323 (2013).

    Article  Google Scholar 

  6. 6

    Meador, K. J. et al. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. Lancet Neurol. 12, 244–252 (2013).

    CAS  Article  Google Scholar 

  7. 7

    Turski, C. A. & Ikonomidou, C. Neuropathological sequelae of developmental exposure to antiepileptic and anesthetic drugs. Front. Neurol. 3, 120 (eCollection 2012).

    Article  Google Scholar 

  8. 8

    Morrell, M. J. & RNS System in Epilepsy Study Group. Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology 77, 1295–1304 (2011).

    Article  Google Scholar 

  9. 9

    Paz, J. T. et al. Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat. Neurosci. 16, 64–70 (2013).

    CAS  Article  Google Scholar 

  10. 10

    Krook-Magnuson, E., Armstrong, C., Oijala, M. & Soltesz, I. On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy. Nat. Commun. 4, 1376 (2013).

    Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Frances E. Jensen.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Jensen, F. Progress across the spectrum of epilepsy research. Nat Rev Neurol 10, 63–64 (2014).

Download citation


Quick links