A key challenge to improving the design of clinical trials in Huntington disease (HD) has been the limited data on the natural history of HD. A recent prospective longitudinal study has provided important information in this regard, which could be useful for future translation of disease-modifying therapies for early-stage HD.
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Barker, R., Mason, S. Mapping the natural history of Huntington disease. Nat Rev Neurol 10, 12–13 (2014). https://doi.org/10.1038/nrneurol.2013.253
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DOI: https://doi.org/10.1038/nrneurol.2013.253