Gene therapy approaches for glioblastoma multiforme (GBM) have been under investigation in clinical trials since the 1990s, but the results to date have been disappointing. A recently published phase III trial of adenovirus-based gene therapy for GBM has demonstrated modest—but possibly clinically relevant—improvements in patient survival.
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Castro, M., Lowenstein, P. The long and winding road—gene therapy for glioma. Nat Rev Neurol 9, 609–610 (2013). https://doi.org/10.1038/nrneurol.2013.198
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DOI: https://doi.org/10.1038/nrneurol.2013.198