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Alzheimer disease

AD pathology—emerging subtypes or age-of-onset spectrum?

Nature Reviews Neurology volume 8, pages 11–12 (2012)Cite this article

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A new cross-sectional study proposes three subtypes of Alzheimer disease: hippocampal-sparing, typical and limbic-predominant, associated with average lifespans of 72, 79 and 86 years, respectively. A longitudinal view suggests that age might be a major neuropathological determinant, with typical cases having younger onset and limbic-predominant cases having older onset.

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References

  1. Murray, M. E. et al. Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study. Lancet Neurol. 10, 785–796 (2011).

    Article  Google Scholar 

  2. Blessed, G., Tomlinson, B. E. & Roth, M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br. J. Psychiatry 114, 797–811 (1968).

    Article  CAS  Google Scholar 

  3. Terry, R. D., Gonatas, N. K. & Weiss, M. Ultrastructural studies in Alzheimer's presenile dementia. Am. J. Pathol. 44, 269–297 (1964).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Katzman, R. Editorial: The prevalence and malignancy of Alzheimer disease. A major killer. Arch. Neurol. 33, 217–218 (1976).

    Article  CAS  Google Scholar 

  5. Braak, H. & Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82, 239–259 (1991).

    Article  CAS  Google Scholar 

  6. Kawas, C. H. & Corrada, M. M. Alzheimer's and dementia in the oldest-old: a century of challenges. Curr. Alzheimer Res. 3, 411–419 (2006).

    Article  CAS  Google Scholar 

  7. Hansen, L. A., DeTeresa, R., Davies, P. & Terry, R. D. Neocortical morphometry, lesion counts, and choline acetyltransferase levels in the age spectrum of Alzheimer's disease. Neurology 38, 48–54 (1988).

    Article  CAS  Google Scholar 

  8. Nelson, P. T. et al. Alzheimer's disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies. Acta Neuropathol. 121, 571–587 (2011).

    Article  Google Scholar 

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Authors and Affiliations

  1. Departments of Neurosciences and Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093-0624, CA, USA

    Eliezer Masliah & Lawrence A. Hansen

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  1. Eliezer Masliah
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  2. Lawrence A. Hansen
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Correspondence to Eliezer Masliah.

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The authors declare no competing financial interests.

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Masliah, E., Hansen, L. AD pathology—emerging subtypes or age-of-onset spectrum?. Nat Rev Neurol 8, 11–12 (2012). https://doi.org/10.1038/nrneurol.2011.205

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