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Neuropsychiatric disorders

Othello syndrome—at the interface of neurology and psychiatry


Othello syndrome, as demonstrated by Shakespeare's fictional character of that name, describes individuals with severe delusional jealousy. Retrospective analysis of data from patients with this syndrome suggests that it is frequently associated with neurological disorders, particularly those affecting the right frontal lobe. What are the implications of these findings?

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  1. Graff-Radford, J., Whitwell, J. L., Geda, Y. E. & Joseph, K. A. Clinical and imaging features of Othello's syndrome. Eur. J. Neurol. doi:10.1111/j.1468-1331.2011.03412.x.

    Article  Google Scholar 

  2. Todd, J. & Dewhurst, K. The Othello syndrome; a study in the psychopathology of sexual jealousy. J. Nerv. Ment. Dis. 122, 367–374 (1955).

    Article  CAS  Google Scholar 

  3. Easton, J., Shackelford, T. K. & Schipper, L. D. Delusional disorder-jealous type: how inclusive are the DSM-IV diagnostic criteria? J. Clin. Psychol. 64, 264–275 (2008).

    Article  Google Scholar 

  4. Ismail, Z. et al. Neurobiology of delusions in Alzheimer's disease. Curr. Psychiatry Rep. 13, 211–218 (2011).

    Article  Google Scholar 

  5. Devinsky, O. Delusional misidentification and duplication: right brain lesions, left brain delusions. Neurology 72, 80–87 (2009).

    Article  Google Scholar 

  6. Braun, C. M. J. & Suffren, S. A general neuropsychological model of delusion. Cogn. Neuropsychiatry 16, 1–39 (2011).

    Article  Google Scholar 

  7. Nagahama, Y., Okina, T., Suzuki, N. & Matsuda, M. Neural correlates of psychotic symptoms in dementia with Lewy bodies. Brain 133, 557–567 (2010).

    Article  Google Scholar 

  8. Soyka, M. & Schmidt, P. Prevalence of delusional jealousy in psychiatric disorders. J. Forensic Sci. 56, 450–452 (2011).

    Article  Google Scholar 

  9. Bleuler, E. Dementia praecox oder gruppe der schizophrenien. Deuticke. Leipzig, Germany (1911).

  10. Lui, S. et al. Association of cerebral deficits with clinical symptoms in antipsychotic-naive first-episode schizophrenia: an optimized voxel-based morphometry and resting state functional connectivity study. Am. J. Psychiatry 166, 196–205 (2009).

    Article  Google Scholar 

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I thank J. Perez-Parada and W. Johnston for helpful comments.

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Camicioli, R. Othello syndrome—at the interface of neurology and psychiatry. Nat Rev Neurol 7, 477–478 (2011).

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