Levodopa treatment alleviates the motor symptoms that characterize Parkinson disease, but is associated with motor complications. Treatments that prolong the action of levodopa could potentially reduce the risk of these adverse events, but a new study reports that one such approach—entacapone as an adjunct to levodopa–carbidopa—is associated with earlier dyskinesia onset than with levodopa–carbidopa alone.
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J. J. Ferreira has acted as a consultant for and received honoraria for lectures from Lundbeck, Novartis and Teva Pharmaceuticals, he has also received research support from Lundbeck and Teva Pharmaceuticals. C. Sampaio declares no competing interests.
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Sampaio, C., Ferreira, J. Adjunctive entacapone therapy increases risk of dyskinesia. Nat Rev Neurol 6, 590–591 (2010). https://doi.org/10.1038/nrneurol.2010.158