Sialorrhea is a common and often debilitating, socially isolating and embarrassing symptom for patients with Parkinson disease (PD). The treatment of sialorrhea involves the management of saliva production, and is complicated in this disease by the risk of aspiration. Two novel approaches to the treatment of this symptom in PD have recently been published.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Parkinson, J. An Essay on the Shaking Palsy (Sherwood, Neeley and Jones, London, 1817).
Eadie, M. J. & Tyrer, J. H. Alimentary disorder in parkinsonism. Australas. Ann. Med. 14, 13–22 (1965).
Leibner, J. et al. The impact of and the factors associated with drooling in Parkinson's disease. Parkinsonism Relat. Disord. doi:10.1016/j.parkreldis.2009.12.003.
South, A. R., Somers, S. M. & Jog, M. S. Gum chewing improves swallow frequency and latency in Parkinson patients: a preliminary study. Neurology 74, 1198–1202 (2010).
Arbouw, M. E. et al. Glycopyrrolate for sialorrhea in Parkinson disease: a randomized, double-blind, crossover trial. Neurology 74, 1203–1207 (2010).
Proulx, M., de Courval, F. P., Wiseman, M. A. & Panisset, M. Salivary production in Parkinson's disease. Mov. Disord. 20, 204–207 (2005).
Edwards, L. L., Quigley, E. M. & Pfeiffer, R. F. Gastrointestinal dysfunction in Parkinson's disease: frequency and pathophysiology. Neurology 42, 726–732 (1992).
Nóbrega, A. C., Rodrigues, B. & Melo, A. Is silent aspiration a risk factor for respiratory infection in Parkinson's disease patients? Parkinsonism Relat. Disord. 14, 646–648 (2008).
Nóbrega, A. C., Rodrigues, B. & Melo, A. Silent aspiration in Parkinson's disease patients with diurnal sialorrhea. Clin. Neurol. Neurosurg. 110, 117–119 (2008).
Fernandez, H. H. & Lapane, K. L. Predictors of mortality among nursing home residents with a diagnosis of Parkinson's disease. Med. Sci. Monit. 8, CR241–CR246 (2002).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Troche, M., Fernandez, H. Sialorrhea and Parkinson disease—novel treatment approaches. Nat Rev Neurol 6, 423–424 (2010). https://doi.org/10.1038/nrneurol.2010.107
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2010.107
