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Alzheimer disease

Visual rating of atrophy aids diagnostic accuracy

The need for early diagnosis of Alzheimer disease is gathering importance with the prospect of disease-modifying therapy. Medial temporal lobe atrophy on MRI is a characteristic, early and predictive feature of the disease. A new visual rating system has been proposed to facilitate assessment of such atrophy in routine clinical practice.

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Figure 1: MRI brain scans from a patient with pathologically proven Alzheimer disease.

References

  1. Ferri, C. P. et al. Global prevalence of dementia: a Delphi consensus study. Lancet 366, 2112–2117 (2005).

    Article  Google Scholar 

  2. Duara, R. et al. Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease. Neurology 71, 1986–1992 (2008).

    Article  CAS  Google Scholar 

  3. Dubois, B. et al. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria. Lancet Neurol. 6, 734–746 (2007).

    Article  Google Scholar 

  4. Waldemar, G. et al. Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline. Eur. J. Neurol. 14, e1–e26 (2007).

    Article  CAS  Google Scholar 

  5. Knopman, D. S. et al. Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 56, 1143–1153 (2001).

    Article  CAS  Google Scholar 

  6. DeCarli, C. et al. Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia. Arch. Neurol. 64, 108–115 (2007).

    Article  Google Scholar 

  7. Jack, C. R. Jr et al. Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. Neurology 58, 750–757 (2002).

    Article  Google Scholar 

  8. Bobinski, M. et al. The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease. Neuroscience 95, 721–725 (2000).

    Article  CAS  Google Scholar 

  9. Scheltens, P. et al. Atrophy of medial temporal lobes on MRI in “probable” Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. J. Neurol. Neurosurg. Psychiatry 55, 967–972 (1992).

    Article  CAS  Google Scholar 

  10. Chan, D. et al. Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease. Ann. Neurol. 49, 433–442 (2001).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Nick C. Fox.

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The authors declare no competing financial interests.

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Ryan, N., Fox, N. Visual rating of atrophy aids diagnostic accuracy. Nat Rev Neurol 5, 243–244 (2009). https://doi.org/10.1038/nrneurol.2009.52

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