An analysis of 12 different second-generation antidepressants rated sertraline and escitalopram as having the most favorable balance between benefit and harm for the treatment of major depressive disorder in adults. A second look at the methods and results from the study reveals that such a positive conclusion might not be warranted.
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References
Cipriani, A. et al. Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. Lancet 373, 746–758 (2009).
Parikh, S. V. Antidepressants are not all created equal. Lancet 373, 700–701 (2009).
Glenny, A. M. et al. Indirect comparisons of competing interventions. Health Technol. Assess. 9, 1–134 (2005).
Bagby, R. M., Ryder, A. G., Schuller, D. R. & Marshall, M. B. The Hamilton Depression Rating Scale: has the gold standard become a lead weight? Am. J. Psychiatry 161, 2163–2177 (2004).
Moher, D. et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? Lancet 352, 609–613 (1998).
Gartlehner, G. et al. Comparative benefits and harms of second-generation antidepressants: background paper for the American College of Physicians. Ann. Intern. Med. 149, 734–750 (2008).
Altman, D. G., Deeks, J. J. & Sackett, D. L. Odds ratios should be avoided when events are common. BMJ 317, 1318 (1998).
Deeks, J. J. Issues in the selection of a summary statistic for meta-analysis of clinical trials with binary outcomes. Stat. Med. 21, 1575–1600 (2002).
Qaseem, A., Snow, V., Denberg, T. D., Forciea, M. A. & Owens, D. K. Using second-generation antidepressants to treat depressive disorders: a clinical practice guideline from the American College of Physicians. Ann. Intern. Med. 149, 725–733 (2008).
Acknowledgements
We would like to thank Kathleen N. Lohr, at the Research Triangle Institute International, and Bradley N. Gaynes, at the Department of Psychiatry, University of North Carolina School of Medicine, for valuable comments on an early draft of this article.
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Gartlehner, G., Hansen, R. Are some antidepressants better than others?. Nat Rev Neurol 5, 239–240 (2009). https://doi.org/10.1038/nrneurol.2009.51
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DOI: https://doi.org/10.1038/nrneurol.2009.51
