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Multiple sclerosis

TNFRSF1A, TRAPS and multiple sclerosis

A genome-wide association study has identified the R92Q variant of the TNFRSF1A gene as a new susceptibility locus for multiple sclerosis. This locus is of special interest because the R92Q substitution was previously detected in a group of multiple sclerosis patients who had additional symptoms compatible with the autoinflammatory syndrome TRAPS.

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R. Hohlfeld is supported by the German Research Foundation (grant number SFB 571, A1).

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T. Kümpfel has acted as a consultant for and received grants from Bayer Schering Pharma, Biogen-Idec, Merck-Serono and Teva. R. Hohlfeld has acted as a consultant for and received grants from Bayer Schering Pharma, Biogen-Idec Merck-Serono, Novartis and Teva.

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Kümpfel, T., Hohlfeld, R. TNFRSF1A, TRAPS and multiple sclerosis. Nat Rev Neurol 5, 528–529 (2009).

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