News & Views

Genetics: An integrated genetic analysis of disease

A genome-wide association study (GWAS) of quantitative traits that incorporated data from GWAS of complex diseases provides clues regarding the relationships between genetic loci, intermediate phenotypes and diseases. Together, the data demonstrate pleiotropy, genetic correlation and cell-type specificity of quantitative traits as predictors of multiple complex diseases.

  • Subscribe to Nature Reviews Nephrology for full access:

    $199

    Subscribe

Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.

References

  1. 1.

    et al. 10 years of GWAS discovery: biology, function, and translation. Am. J. Hum. Genet. 101, 5–22 (2017).

  2. 2.

    et al. Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. Nat. Genet. 50, 390–400 (2018).

  3. 3.

    , , , & Pleiotropy in complex traits: challenges and strategies. Nat. Rev. Genet. 14, 483–495 (2013).

  4. 4.

    et al. Cross-sectional analysis of biobank Japan clinical data: a large cohort of 200,000 patients with 47 common diseases. J. Epidemiol. 27, S2–S8 (2017).

  5. 5.

    et al. Overview of the biobank Japan project: study design and profile. J. Epidemiol. 27, S9–S21 (2017).

  6. 6.

    et al. Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat. Genet. 47, 1228–1235 (2015).

  7. 7.

    Roadmap Epigenomics Consortium et al. Integrative analysis of 111 reference human epigenomes. Nature 518, 317–330 (2015).

  8. 8.

    , , , & Calcium urolithiasis, blood pressure and salt intake. Blood Press. 12, 122–127 (2003).

  9. 9.

    , & Ushering hypertension into a new era of precision medicine. JAMA 315, 343–344 (2016).

Download references

Acknowledgements

D.L.M. is supported by NIH Grants DK96859 and HL116264 and the American Heart Association (AHA) 15SFRN2391002.

Author information

Affiliations

  1. Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.

    • David L. Mattson

Authors

  1. Search for David L. Mattson in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to David L. Mattson.