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Angiomyolipoma

A link between stemness and tumorigenesis in the kidney

Nature Reviews Nephrology volume 14, pages 215–216 (2018)Cite this article

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The cellular origins of angiomyolipoma and other tuberous sclerosis complex-associated neoplasms are unknown. Now, two studies show that these neoplasms derive from cancer stem cells that originate from multipotent renal epithelial cells. The new findings provide a link between stemness and tumorigenesis in the kidney.

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Figure 1: Models of kidney regeneration and angiomyolipoma tumorigenesis.

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Acknowledgements

P.R. is supported by the European Research Council under the Consolidator Grant RENOIR (ERC-2014-CoG), grant number 648274.

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Authors and Affiliations

  1. Department of Biomedical Experimental and Clinical Sciences “Mario Serio”, the Excellence Centre for Research, Transfer and High Education DENOTHE, University of Florence, Florence, Italy

    Francesca Becherucci & Paola Romagnani

  2. Pediatric Nephrology Unit, Meyer Children's Hospital, Florence, Italy

    Francesca Becherucci & Paola Romagnani

Authors
  1. Francesca Becherucci
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  2. Paola Romagnani
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Correspondence to Paola Romagnani.

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The authors declare no competing financial interests.

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Becherucci, F., Romagnani, P. A link between stemness and tumorigenesis in the kidney. Nat Rev Nephrol 14, 215–216 (2018). https://doi.org/10.1038/nrneph.2018.16

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