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Angiomyolipoma: A link between stemness and tumorigenesis in the kidney

Nature Reviews Nephrology volume 14, pages 215216 (2018) | Download Citation

The cellular origins of angiomyolipoma and other tuberous sclerosis complex-associated neoplasms are unknown. Now, two studies show that these neoplasms derive from cancer stem cells that originate from multipotent renal epithelial cells. The new findings provide a link between stemness and tumorigenesis in the kidney.

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Acknowledgements

P.R. is supported by the European Research Council under the Consolidator Grant RENOIR (ERC-2014-CoG), grant number 648274.

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Affiliations

  1. Department of Biomedical Experimental and Clinical Sciences “Mario Serio”, the Excellence Centre for Research, Transfer and High Education DENOTHE, University of Florence, Florence, Italy.

    • Francesca Becherucci
    •  & Paola Romagnani
  2. Pediatric Nephrology Unit, Meyer Children's Hospital, Florence, Italy.

    • Francesca Becherucci
    •  & Paola Romagnani

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Paola Romagnani.

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DOI

https://doi.org/10.1038/nrneph.2018.16