Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Glomerular disease

Updated Oxford Classification of IgA nephropathy: a new MEST-C score

The Oxford Classification of IgA nephropathy (IgAN) is the most widely accepted system for assessing histologic findings in IgAN. A new publication refines this classification by adding a crescent score, reassessing the segmental sclerosis score, and contextualizing the clinical relevance of the histologic lesions.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Moriyama, T. et al. Prognosis in IgA nephropathy: 30-year analysis of 1,012 patients at a single center in Japan. PLoS ONE 9, e91756 (2014).

  2. Cattran, D. C. et al. The Oxford classification of IgA nephropathy: rationale, clinicopathologic correlations, and classification. Kidney Int. 76, 534–545 (2009).

    Article  Google Scholar 

  3. Roberts, I. S. D. et al. The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility. Kidney Int. 76, 546–556 (2009).

    Article  Google Scholar 

  4. Trimarchi, H. et al. Oxford classification of IgA nephropathy 2016: an update from the IgA nephropathy classification working group. Kidney Int. 91, 1014–1021 (2017).

    Article  Google Scholar 

  5. Tumlin, J. A. & Hennigar, R. A. Clinical presentation, natural history, and treatments of crescentic proliferative IgA nephropathy. Semin. Nephrol. 24, 256–268 (2004).

    Article  Google Scholar 

  6. Avasare, R. S. et al. Predicting post-transplant recurrence of IgA nephropathy: the importance of crescents. Am. J. Nephrol. 45, 99–106 (2017).

    Article  CAS  Google Scholar 

  7. Lv, J. et al. Evaluation of the Oxford classification of IgA nephropathy: a systemic review and meta-analysis. Am. J. Kidney Dis. 62, 891–899 (2013).

    Article  Google Scholar 

  8. Haas, M. et al. A multicenter study of the predictive value of crescents in IgA nephropathy. J. Am. Soc. Nephrol. 28, 691–701 (2017).

    Article  CAS  Google Scholar 

  9. Barbour, S. J. et al. The MEST score provides earlier risk prediction in IgA nephropathy. Kidney Int. 9, 167–175 (2016).

    Article  Google Scholar 

  10. Bellur, S. S. et al. Evidence from the Oxford classification cohort supports the clinical value of subclassification of focal segmental glomerulosclerosis in IgA nephropathy. Kidney Int. 91, 235–243 (2017).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Glen Markowitz.

Ethics declarations

Competing interests

The author declares no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Markowitz, G. Updated Oxford Classification of IgA nephropathy: a new MEST-C score. Nat Rev Nephrol 13, 385–386 (2017). https://doi.org/10.1038/nrneph.2017.67

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2017.67

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing