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Renal physiology

Burning calories to excrete salt

Nature Reviews Nephrology volume 13, pages 323–324 (2017)Cite this article

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New findings challenge the dogma that high salt intake leads to increased thirst, water intake and diuresis. Titze and colleagues show that salt loading activates an adaptive regulatory network in the kidney, muscle and liver, which enables the reprioritization of energy metabolism to conserve plasma water in the setting of high salt intake.

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Figure 1: Mechanism of water conservation in the presence of high salt intake.

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  1. Department of Medicine, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands

    Ton J. Rabelink

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  1. Ton J. Rabelink
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Correspondence to Ton J. Rabelink.

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The author declares no competing financial interests.

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Rabelink, T. Burning calories to excrete salt. Nat Rev Nephrol 13, 323–324 (2017). https://doi.org/10.1038/nrneph.2017.62

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