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Glomerular disease

Crescentic glomerulonephritis: beyond the immune system

T cells mediate injury in glomerulonephritis but mice devoid of T cells and B cells can also develop this disease. A new study shows that expression of the cytokine receptor common subunit γ and IL-15 in podocytes protects against crescentic glomerulonephritis, independent of B cells, T cells and natural killer cells.

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Figure 1: Immune status and cytokine receptor common subunit γ (γc) expression levels in different strains of mice with nephrotoxic nephritis.


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Correspondence to Charles Pusey.

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Webster, P., Pusey, C. Crescentic glomerulonephritis: beyond the immune system. Nat Rev Nephrol 13, 198–200 (2017).

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